In the cases of some infections, such as mice infected with adenovirus, the generation of effector cytotoxic CD8 T cell responses needed to clear the infection is dependent on the antigen-presenting dendritic cells receiving stimulation through the CD40 receptor on their surface, a process known as dendritic cell 'licensing'. In this infection system, the dendritic cell would likely receive CD40 receptor stimulation from:
A) The activation of a TLR expressed in the dendritic cell
B) The up-regulation of CD40 ligand by virus-infected host cells
C) The activation of cytosolic nucleic acid sensors in the dendritic cell
D) The interaction with a CD4 effector cell expressing CD40 ligand
E) The phagocytosis of apoptotic cell debris resulting from the virus infection

Question

Quizplus · Accepted Answer

CD40 receptor stimulation on dendritic cells can be initiated by interaction with CD4 effector cells expressing CD40 ligand (CD40L), leading to dendritic cell licensing and subsequent activation of cytotoxic CD8 T cells.

In the Cases of Some Infections, Such as Mice Infected