It is well documented that antibody affinities for an immunizing antigen continue to increase upon successive rounds of immunization (i.e., secondary, tertiary, etc.). This is due to the fact that:
A) At each round of immunization, new naive B cells are recruited into the response.
B) At each round of immunization, the expression of AID increases, leading to higher rates of somatic hypermutation.
C) Memory B cells express higher levels of AID than naive B cells, leading to higher rates of somatic hypermutation.
D) Memory B cells can re-enter germinal centers and undergo additional somatic hypermutation.
E) At each round of immunization, germinal centers become larger and have increased numbers of B cells in them.

Question

Quizplus · Accepted Answer

Memory B cells can re-enter germinal centers and undergo additional somatic hypermutation, which leads to increased antibody affinity for the antigen upon successive rounds of immunization.

It Is Well Documented That Antibody Affinities for an Immunizing