Question 1

2,3-bisphosphoglycerate binds only to the _____________ form of hemoglobin.

Accepted Answer

T, or deoxy

Question 2

The ability of myoglobin to bind oxygen depends on the presence of a bound prosthetic group called _____________.

Accepted Answer

heme

Question 3

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: This condition is a result of a single point mutation in the β chain of hemoglobin.

Accepted Answer

Sickle-cell anemia is a genetic disorder caused by a single point mutation in the β chain of hemoglobin.

Question 4

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: This method of studying hemoglobin monitors changes in magnetic fields during the binding of oxygen.

Accepted Answer

fMRI stands for functional magnetic resonance imaging, which is a non-invasive way of monitoring changes in magnetic fields in the brain. In the context of studying hemoglobin, fMRI would be used to monitor changes in magnetic fields during the binding of oxygen.

Question 5

Under normal conditions, the heme iron in myoglobin and hemoglobin is in the _____________ oxidation state.

Accepted Answer

The answer of Under normal conditions, the heme iron in...

Question 6

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The type of hemoglobin that is composed of two α chains and two γ chains.

Accepted Answer

Fetal hemoglobin is composed of two α chains and two γ chains, whereas adult hemoglobin is composed of two α chains and two β chains.

Question 7

The effect of pH on oxygen binding of hemoglobin is referred to as the _____________.

Accepted Answer

The answer of The effect of pH on oxygen binding...

Question 8

The form of hemoglobin found in the R state is called _____________.

Accepted Answer

The answer of The form of hemoglobin found in the...

Question 9

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The shape of the myoglobin binding curve that shows that it is not regulated allosterically.

Accepted Answer

The term "hyperbolic" refers to the shape of the myoglobin binding curve, which is a rectangular hyperbola. This shape indicates that myoglobin binds oxygen with high affinity but does not exhibit cooperativity or allosteric regulation.

Question 10

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Choose the correct answer from the list below. Not all of the answers will be used.
-____________: This iron atom in heme is bound to the fifth coordination site of the molecule.

Accepted Answer

The fifth coordination site in the heme molecule is occupied by a histidine amino acid residue.

Question 11

The binding of 2,3-bisphosphoglycerate to hemoglobin _____________ (increases, decreases) its affinity of oxygen binding.

Accepted Answer

The answer of The binding of 2,3-bisphosphoglycerate to hemoglobin _____________...

Question 12

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The molecule whose function is to facilitate diffusion of oxygen in muscle cells.

Accepted Answer

Myoglobin is the molecule whose function is to facilitate diffusion of oxygen in muscle cells.

Question 13

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: This is the chemical form in which most of the carbon dioxide is transported in the blood.

Accepted Answer

Bicarbonate ion is the most common form in which carbon dioxide is transported in the blood.

Question 14

Carbon dioxide reacts with the amino-terminal groups of hemoglobin to form carbamate groups, which carry a(n) _____________ charge.

Accepted Answer

The answer of Carbon dioxide reacts with the amino-terminal groups...

Question 15

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The substance produced when carbon dioxide reacts with water.

Accepted Answer

The answer of Use the following to answer questions
Choose the...

Question 16

As the partial pressure of carbon dioxide increases, the affinity of oxygen binding to hemoglobin _____________.

Accepted Answer

The answer of As the partial pressure of carbon dioxide...

Question 17

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The organic portion of the heme group in hemoglobin.

Accepted Answer

Protoporphyrin is the organic portion of the heme group in hemoglobin.

Question 18

In normal adult hemoglobin, HbA, the β6 position is a glutamate residue, whereas in sickle-cell hemoglobin, HbS, it is a(n) _____________ residue.

Accepted Answer

The answer of In normal adult hemoglobin, HbA, the β6...

Question 19

Use the following to answer questions
Choose the correct answer from the list below. Not all of the answers will be used.
-____________: The type of binding that is indicated by a sigmoidal-shaped binding curve.

Accepted Answer

A sigmoidal-shaped binding curve indicates cooperative binding, where the binding of one molecule affects the binding of additional molecules. Myoglobin and hemoglobin are examples of proteins that exhibit cooperative binding.

Question 20

The T state of hemoglobin is stabilized by a salt bridge between β1 Asp 94 and the C-terminal _____________ of the β1 chain.

Accepted Answer

The answer of The T state of hemoglobin is stabilized...

Quiz 9: Hemoglobin: an Allosteric Protein

2,3-bisphosphoglycerate binds only to the _____________ form of hemoglobin.

The ability of myoglobin to bind oxygen depends on the presence of a bound prosthetic group called _____________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: This condition is a result of a single point mutation in the β chain of hemoglobin.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: This method of studying hemoglobin monitors changes in magnetic fields during the binding of oxygen.

Under normal conditions, the heme iron in myoglobin and hemoglobin is in the _____________ oxidation state.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The type of hemoglobin that is composed of two α chains and two γ chains.

The effect of pH on oxygen binding of hemoglobin is referred to as the _____________.

The form of hemoglobin found in the R state is called _____________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The shape of the myoglobin binding curve that shows that it is not regulated allosterically.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: This iron atom in heme is bound to the fifth coordination site of the molecule.

The binding of 2,3-bisphosphoglycerate to hemoglobin _____________ (increases, decreases) its affinity of oxygen binding.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The molecule whose function is to facilitate diffusion of oxygen in muscle cells.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: This is the chemical form in which most of the carbon dioxide is transported in the blood.

Carbon dioxide reacts with the amino-terminal groups of hemoglobin to form carbamate groups, which carry a(n) _____________ charge.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The substance produced when carbon dioxide reacts with water.

As the partial pressure of carbon dioxide increases, the affinity of oxygen binding to hemoglobin _____________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The organic portion of the heme group in hemoglobin.

In normal adult hemoglobin, HbA, the β6 position is a glutamate residue, whereas in sickle-cell hemoglobin, HbS, it is a(n) _____________ residue.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -____________: The type of binding that is indicated by a sigmoidal-shaped binding curve.

The T state of hemoglobin is stabilized by a salt bridge between β1 Asp 94 and the C-terminal _____________ of the β1 chain.