At Body Temperature, Many Proteins Have a Well-Defined Structure That $\Delta$

At body temperature, many proteins have a well-defined structure that is essential to their function. As the temperature is raised, however, the structure changes and the protein is no longer functional. This is referred to as protein denaturation. What can be deduced from this information about the signs of the enthalpy and entropy changes for denaturation?

A) " $\Delta$ H" > 0 and " $\Delta$ S" > 0
B) " $\Delta$ H" > 0 and " $\Delta$ S" < 0
C) " $\Delta$ H" < 0 and " $\Delta$ S" > 0
D) " $\Delta$ H" < 0 and " $\Delta$ S" < 0
E) There is insufficient information to deduce anything about the signs of $\Delta$ H and $\Delta$ S.