A 35-Year-Old Women Is Brought to the Hospital Due to Fever

A 35-year-old women is brought to the hospital due to fever, chills and malaise. She has a history of reccurent urinary tract infection. The patient is febrile, tachycardic, and hypotensive. on exam, she has a costovertebral angle tenderness. urinalysis shows many white blood cell. An imaging reveales a nephrogenic abscess. The patient is prescribed an intravenous antibiotic administered every 12 hours.  Calculation of the maintenance dose will most likely require which of the following parameters?

A) Drug clearance rate
B) Number of doses needed to reach steady state
C) Size of the loading dose
D) Total body weight of the patient
E) Volume of distribution of the drug