A pharmacist is developing a new medication to treat a resistant psudomonaus infection. It has a volume of distribution of 11L. It is eliminated by first-order kinetics and has a half-life of 10 hours. If given by a continuous infusion, approximately how much time would it require for the drug to achieve a 95% plasma steady state concentration?

Question

A pharmacist is developing a new medication to treat a resistant psudomonaus infection. It has a volume of distribution of 11L.  It is eliminated by first-order kinetics and has a half-life of 10 hours.  If given by a continuous infusion, approximately how much time would it require for the drug to achieve a 95% plasma steady state concentration?

Quizplus · Accepted Answer

Eductional Objective: During continuous infusion of a drug metabolized by first-order kinetics, the steady state concentration is reached in 4 to 5 half-lives.

A Pharmacist Is Developing a New Medication to Treat a Resistant