A 47-year-old man with gastroesophageal reflux disease comes to the physician because of severe burning chest pain and belching after meals. He has limited his caffeine intake and has been avoiding food close to bedtime. Esophagogastroduodenoscopy shows erythema and erosions in the distal esophagus. Which of the following is the mechanism of action of the most appropriate drug for this patient?

Question

Quizplus · Accepted Answer

Eductional Objective: Proton pump inhibitors (PPIs) irreversibly inhibit H+/K+ ATPase in parietal cells of the stomach and thus reduce the ATP-dependent secretion of H+ ions into the gastric lumen. They are considered first-line for patients with severe GERD.

A 47-Year-Old Man with Gastroesophageal Reflux Disease Comes to the Physician