You are studying the effects of an experimental compound on the process of glucose metabolism in laboratory animals. Addition of the compound to the animal chow is associated with decreased glucose output by the liver of these animals. Analysis of liver biopsy cells isolated 2-days following compound addition indicates that citrate transport into the cytosol is impaired. The activity of which of the following glycolytic enzymes is most likely to be affected by your experimental compound?

Question

Quizplus · Accepted Answer

PFK1 represents the rate-limiting enzyme of glycolysis. This enzyme is subject to allosteric regulation, both positive and negative, by numerous effectors including citrate, which normally inhibits the enzyme allowing carbons to be diverted into glucose via gluconeogenesis

You Are Studying the Effects of an Experimental Compound on the Process