Which of the following is the final step in the coagulation cascade, leading to clot formation?

Question

Quizplus · Accepted Answer

The final step in the coagulation cascade is the thrombin-catalyzed conversion of fibrinogen to fibrin, which forms a stable clot. Thrombin-mediated release of the fibrinopeptides generates fibrin monomers that spontaneously aggregate in a regular array, forming a somewhat weak fibrin clot. In addition to fibrin activation, thrombin converts factor XIII to factor XIIIa, a highly specific transglutaminase that introduces cross-links composed of covalent bonds between the amide nitrogen of glutamines and e-amino group of lysines in the fibrin monomers forming a stable clot.

Which of the Following Is the Final Step in the Coagulation