Accumulating Evidence Indicates That the Nonsteroidal Anti-Inflammatory (NSAID) Aspirin Is

Accumulating evidence indicates that the nonsteroidal anti-inflammatory (NSAID) aspirin is effective in the control of numerous chronic conditions such as atherosclerosis. The principal cardiovascular benefit from aspirin is due to its ability to reduce the incidence and severity of thrombotic episodes. The anticoagulant effect of aspirin occurs through its ability to inhibit which of the following activities?

A) cyclooxygenase
B) fibrin cross-linking by factor XIIIa
C) phospholipase A₂
D) thrombin binding to activated platelets
E) von Willebrand factor