Question 1

Match the type of apoptosis with the involved item:
-Apoptosis Induced by Tumor Necrosis Factor Family of Receptors

Accepted Answer

FasL is a member of the tumor necrosis factor family of receptors that can induce apoptosis.

Question 2

Match the type of apoptosis with the involved item:
-Cytotoxic T-Lymphocyte-Mediated Apoptosis

Accepted Answer

Cytotoxic T-Lymphocyte-Mediated Apoptosis involves Granzyme B, which is released by cytotoxic T cells to induce apoptosis in target cells.

Question 3

The ER is involved in metabolism of various chemicals via cytochrome P-450 and cells exposed to these chemicals show 	of ER. Mitochondrial and cytoskeletal abnormalities are also apparent in injured cells.

Accepted Answer

The smooth endoplasmic reticulum (ER) is involved in the metabolism of various chemicals via cytochrome P-450 enzymes. When cells are exposed to these chemicals, the smooth ER undergoes hypertrophy as it increases in size to handle the increased metabolic demand.

Question 4

Match the abnormality which results in intracellular accumulations in nonneoplatics
cells with the resultant disease:
-Abnormal metabolism

Accepted Answer

Fatty change in the liver, also known as hepatic steatosis, is a result of abnormal metabolism where there is an accumulation of triglycerides within liver cells.

Question 5

Match the abnormality which results in intracellular accumulations in nonneoplatics
cells with the resultant disease:
-Mutations causing alterations in protein folding and transport

Accepted Answer

Mutations causing alterations in protein folding and transport are characteristic of Alpha1-antitrypsin deficiency, leading to the accumulation of misfolded proteins within cells.

Question 6

Match the abnormality which results in intracellular accumulations in nonneoplatics
cells with the resultant disease:
-Deﬁciencies in critical enzymes

Accepted Answer

Lysosomal storage diseases are caused by deficiencies in critical enzymes, leading to the accumulation of substrates within lysosomes.

Question 7

Match the abnormality which results in intracellular accumulations in nonneoplatics
cells with the resultant disease:
-Inability to degrade phagocytosed particles

Accepted Answer

Hemosiderosis is caused by the accumulation of hemosiderin, a storage form of iron, due to the inability to degrade phagocytosed iron-containing particles.

Question 8

How do intracellular hyaline deposits, such as reabsorption droplets, Russell bodies, and Mallory alcoholic hyaline, appear when stained histologically with hematoxylin and eosin?

Accepted Answer

Intracellular hyaline deposits, when stained with hematoxylin and eosin, appear homogeneous and pink due to the eosin dye, which stains proteins and other structures with a pink hue.

Question 9

Which of the following diseases would most likely show glycogen abnormalities if tissues, such as the descending loop of Henle and liver cells, are stained with periodic acid shiﬀ (PAS) ?

Accepted Answer

Diabetes mellitus can lead to glycogen accumulation in tissues, which would be highlighted by PAS staining.

Question 10

Hemosiderin is a hemoglobin-derived, golden yellow-to-brown, granular or crystalline pigment that can indicate a local excess of which of the following?

Accepted Answer

Hemosiderin is an iron-storage complex and its presence indicates an excess of iron, often due to bleeding or iron overload conditions.

Question 11

Bilirubin is hemoglobin-derived and the normal major pigment found in bile. If found in excess, what color does it change the skin?

Accepted Answer

Excess bilirubin in the blood leads to jaundice, which causes the skin and eyes to turn yellow.

Question 12

The deposition of calcium salts in otherwise normal tissues is known as calcification, and it almost always results from secondary to some disturbance in
Calcium metabolism.

Accepted Answer

Metastatic calcification occurs due to hypercalcemia, where calcium salts are deposited in normal tissues as a result of elevated calcium levels in the blood.

Question 13

Which of the following would NOT be associated with metastatic calciﬁcation?

Accepted Answer

Metastatic calcification is associated with hypercalcemia, which can result from increased PTH, bone destruction, vitamin D disorders, or renal failure. Aortic stenosis is not typically related to hypercalcemia or metastatic calcification.

Question 14

Acute and Chronic Inflammation
-Which of the following is associated with acute inﬂammation?

Accepted Answer

Neutrophils are the primary cells involved in acute inflammation, responding quickly to injury or infection.

Question 15

Acute and Chronic Inflammation
-Acute inflammation may be triggered by infections, trauma, physical or chemical agents, tissue necrosis, foreign bodies, and immune reactions. Which of the following is NOT seen in acute inﬂammation?

Accepted Answer

In acute inflammation, there is an increase in blood flow due to vasodilation, not a decrease.

Question 16

Acute and Chronic Inflammation
-Vascular changes associated with acute inflammation include_____ (from histamine and NO) and vascular permeability.

Accepted Answer

Acute inflammation involves vasodilation, primarily due to histamine and nitric oxide, which increases blood flow and vascular permeability to allow immune cells to reach the site of injury.

Question 17

Match the endothelial molecule (leukocyte adhesion molecule) with its major role:
-Rolling, adhesion to activated endothelium (neutrophils, T cells)

Accepted Answer

The answer of Match the endothelial molecule (leukocyte adhesion molecule)...

Question 18

Match the endothelial molecule (leukocyte adhesion molecule) with its major role:
-Adhesion (eosinophils, monocytes, lymphocytes)

Accepted Answer

VCAM-1 (Vascular Cell Adhesion Molecule-1) is primarily involved in the adhesion of eosinophils, monocytes, and lymphocytes to the endothelium.

Question 19

Match the endothelial molecule (leukocyte adhesion molecule) with its major role:
-Leukocyte migration through endothelium

Accepted Answer

CD31 (PECAM) is primarily involved in the transmigration of leukocytes through the endothelium.

Question 20

Match the endothelial molecule (leukocyte adhesion molecule) with its major role:
-Rolling (neutrophils, monocytes, lymphocytes)

Accepted Answer

P-selectin is a major adhesion molecule involved in the rolling of neutrophils, monocytes, and lymphocytes on the endothelial surface.

Quiz 1: Pathology

Match the type of apoptosis with the involved item: -Apoptosis Induced by Tumor Necrosis Factor Family of Receptors

Match the type of apoptosis with the involved item: -Cytotoxic T-Lymphocyte-Mediated Apoptosis

The ER is involved in metabolism of various chemicals via cytochrome P-450 and cells exposed to these chemicals show of ER. Mitochondrial and cytoskeletal abnormalities are also apparent in injured cells.

Match the abnormality which results in intracellular accumulations in nonneoplatics cells with the resultant disease: -Abnormal metabolism

Match the abnormality which results in intracellular accumulations in nonneoplatics cells with the resultant disease: -Mutations causing alterations in protein folding and transport

Match the abnormality which results in intracellular accumulations in nonneoplatics cells with the resultant disease: -Deﬁciencies in critical enzymes

Match the abnormality which results in intracellular accumulations in nonneoplatics cells with the resultant disease: -Inability to degrade phagocytosed particles

How do intracellular hyaline deposits, such as reabsorption droplets, Russell bodies, and Mallory alcoholic hyaline, appear when stained histologically with hematoxylin and eosin?

Which of the following diseases would most likely show glycogen abnormalities if tissues, such as the descending loop of Henle and liver cells, are stained with periodic acid shiﬀ (PAS) ?

Hemosiderin is a hemoglobin-derived, golden yellow-to-brown, granular or crystalline pigment that can indicate a local excess of which of the following?

Bilirubin is hemoglobin-derived and the normal major pigment found in bile. If found in excess, what color does it change the skin?

The deposition of calcium salts in otherwise normal tissues is known as calcification, and it almost always results from secondary to some disturbance in Calcium metabolism.

Which of the following would NOT be associated with metastatic calciﬁcation?

Acute and Chronic Inflammation -Which of the following is associated with acute inﬂammation?

Acute and Chronic Inflammation -Acute inflammation may be triggered by infections, trauma, physical or chemical agents, tissue necrosis, foreign bodies, and immune reactions. Which of the following is NOT seen in acute inﬂammation?

Acute and Chronic Inflammation -Vascular changes associated with acute inflammation include_____ (from histamine and NO) and vascular permeability.

Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Rolling, adhesion to activated endothelium (neutrophils, T cells)

Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Adhesion (eosinophils, monocytes, lymphocytes)

Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Leukocyte migration through endothelium

Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Rolling (neutrophils, monocytes, lymphocytes)