A 15-year-old girl develops malaise,headache,and low-grade fever,followed by pharyngitis and cervical lymph node enlargement as a result of infectious mononucleosis caused by Epstein-Barr virus (EBV).Her acute symptoms resolve within 2 weeks,and the fatigue improves within 3 months.All of the following are required for CD8⁺ cytotoxic T lymphocyte (CTL)recognition and killing of EBV-infected cells EXCEPT: A)($\beta$₂)-Microglobulin B)HLA-A,-B or -C C)CD28 D)LFA-1 (leukocyte function-associated antigen-1) E)TAP (transporter associated with antigen processing)

Question

Quizplus · Accepted Answer

CD28 is not involved in antigen recognition by T cells,but rather,in costimulation.Cell-mediated immunity against intracellular organisms,such as viruses,is largely mediated by class I-restricted T cells,such as cytotoxic T lymphocytes (CTLs).The class I MHC molecules are HLA-A,HLA-B,and HLA-C.CTLs recognize complexes of viral peptides with class I MHC molecules.$\beta$₂-Microglobulin is the nonpolymorphic,noncovalently associated polypeptide chain of MHC class I molecules.TAP is a critical protein involved in the processing and presentation of antigen by class I MHC.LFA-1 is an important integrin mediating adhesion of the CD8⁺ T cells to virus-infected target cells.

A 15-Year-Old Girl Develops Malaise,headache,and Low-Grade Fever,followed by Pharyngitis and Cervical