LFA-1 is an integrin that promotes T cell activation by which one of the following mechanisms?
A)Binds to the$\alpha$3 domain of class I MHC molecules,mediating high avidity between T cells and antigen-presenting cells (APCs)
B)Binds to B7-1 or B7-2 on the surface of APCs,mediating "signal 2"
C)Binds to GlyCAM-1 on high endothelial venules of lymph nodes,mediating rolling of T cells on endothelium
D)Binds to ICAM-1 on the surface of a variety of cells,mediating firm adhesion between T cells and APCs or endothelial cells
E)Binds to VCAM-1 on the surface of cytokine-activated endothelial cells,mediating homing of T cells to peripheral sites of inflammation

Question

Quizplus · Accepted Answer

LFA-1 is an integrin expressed on the surface of leukocytes,which binds ICAM-1 to mediate specific,firm adhesion between T cells and antigen-presenting cells,as well as leukocytes and endothelial cells.As such,it plays an important role in the activation of T lymphocytes and in their migration to sites of infection and inflammation.In contrast,CD8 binds the $\alpha$3 domain of class I MHC molecules,CD28 and CTLA-4 bind B7 proteins,L-selectin is the receptor for GlyCAM-1,and VLA-4 is the receptor for VCAM-1.

LFA-1 Is an Integrin That Promotes T Cell Activation by Which