Which of the following is NOT a property shared by both CD4 and CD8?
A)Binds to nonpolymorphic regions of MHC molecules
B)Cytoplasmic tail associates with the Src family kinase Lck
C)Is a member of the Ig superfamily
D)Functions as a coreceptor for $\alpha$$\beta$ TCRs
E)Is expressed on the majority of mature blood T cells

Question

Which of the following is NOT a property shared by both CD4 and CD8?
A)Binds to nonpolymorphic regions of MHC molecules
B)Cytoplasmic tail associates with the Src family kinase Lck
C)Is a member of the Ig superfamily
D)Functions as a coreceptor for  $\alpha$$\beta$  TCRs
E)Is expressed on the majority of mature blood T cells

Quizplus · Accepted Answer

CD4 is expressed on the majority (~65%)of mature blood T cells,whereas CD8 is expressed on a minority (~35%).Both CD4 and CD8 are transmembrane glycoprotein members of the Ig superfamily,both serve as MHC-binding coreceptors for the T cell receptor,and both participate in early signal transduction events via cytoplasmic tail binding of the Src family tyrosine kinase Lck.

Which of the Following Is NOT a Property Shared by Both