An enzyme-catalyzed reaction rate will be increased if the energy level of ES can be increased. Which of the following will not increase the energy level of ES?
A) destabilization of ES by strain caused by non-covalent interactions between E and S.
B) loss of entropy due to binding of E and S.
C) destabilization of ES by distortion.
D) destabilization of ES by solvation.
E) destabilization of ES by electrostatic effects.

Question

Quizplus · Accepted Answer

Destabilization of ES (enzyme-substrate complex) by solvation typically stabilizes the complex rather than increasing its energy level. Solvation involves the interaction of solvent molecules with the ES complex, which can lead to a more thermodynamically favorable state, thus not increasing the energy level of ES.

An Enzyme-Catalyzed Reaction Rate Will Be Increased If the Energy