Since enzymes are not rigid molecules but rather flexible proteins, which of the following may be attributed to this fact?
A) active sites are able to conform to the shape of the substrate
B) catalytic residues are oriented in such as way to aid in bond breakage and bond formation
C) strain is placed upon the substrate while it binds to the enzyme
D) near-attack conformations are achieved during formation of the transition state during an enzyme catalyzed reaction
E) all of the above are correct

Question

Quizplus · Accepted Answer

All of the above choices are correct. The flexibility of enzymes allows them to adapt to the shape of the substrate, orient catalytic residues for effective bond breakage, place strain on the substrate during binding, and achieve near-attack conformations during transition state formation.

Since Enzymes Are Not Rigid Molecules but Rather Flexible Proteins