Transition-state analogs are:
A) approximations of the transition state that bind more tightly than the substrate.
B) compounds that compete for the active site, but are not necessarily very similar to the substrate.
C) stable molecules that can not be expected to resemble the true transition state too closely.
D) stable chemically and structurally similar molecules to the transition state.
E) all of the above.

Question

Quizplus · Accepted Answer

Transition-state analogs are designed to mimic the transition state of a substrate in an enzyme-catalyzed reaction. They bind more tightly to the enzyme than the substrate itself, competing for the active site. Because they are stable molecules that resemble the transition state, they can be used to study enzyme mechanisms and design inhibitors.

Transition-State Analogs Are