Which of the following are relevant to the reaction catalyzed by chorismate mutase?
A) the reaction involves a concerted intramolecular rearrangement of chorismate to prephenate during the synthesis of phenylalanine.
B) the enzyme catalyzed and uncatalyzed reactions follow almost identical routes
C) the enzymatic reaction is thought to involve transition state stabilization by 12 electrostatic and hydrogen bond interactions
D) the geometry of the enzyme active site is such that the difference in energy between ES and the near attack conformation is less than 1 kJ/mol
E) all of the above are true

Question

Quizplus · Accepted Answer

All of the statements provided are true and relevant to the reaction catalyzed by chorismate mutase. This enzyme facilitates the rearrangement of chorismate to prephenate, a key step in the biosynthesis of the amino acids phenylalanine and tyrosine. The reaction pathway, both catalyzed and uncatalyzed, involves similar transition states, and the enzyme is known to stabilize the transition state through multiple interactions. The active site's geometry minimizes the energy difference between the enzyme-substrate complex and the transition state, making the reaction more efficient.

Which of the Following Are Relevant to the Reaction Catalyzed