If the transition state of an enzyme catalyzed reaction contained a positive charge, which of the following amino acids would most likely be present in the active site to aid in transition state formation?
A) Lys
B) Val
C) Asn
D) Glu
E) Cys

Question

Quizplus · Accepted Answer

Glu (glutamic acid) has a negatively charged side chain at physiological pH, which can stabilize a positively charged transition state through electrostatic interactions.

If the Transition State of an Enzyme Catalyzed Reaction Contained