HIV-1 protease is different from most mammalian aspartic acid proteases in that it has:
A) two subunits each with a two-aspartate active site.
B) two subunits each contributing an aspartate to the active site.
C) two active sites on one protein.
D) two subunits, one with an active site, and the other with a regulatory activity.
E) none of the above.

Question

Quizplus · Accepted Answer

HIV-1 protease is a homodimer, with each subunit contributing an aspartate residue to form the active site, distinguishing it from most mammalian aspartic acid proteases which typically have a single polypeptide chain with two aspartate residues in the active site.

HIV-1 Protease Is Different from Most Mammalian Aspartic Acid Proteases