Which of the following statements regarding enzymes is true?
A) stabilization of the transition state must be less than stabilization of ES for catalysis to occur
B) an enzyme mechanism is vastly different from the uncatalyzed reaction
C) binding of substrate to an enzyme often causes strain, thus promoting transition state formation
D) a random single displacement mechanisms requires that substrates bind to the enzyme in a specific order
E) none of the above

Question

Quizplus · Accepted Answer

Binding of substrate to an enzyme can cause strain, which can promote transition state formation and thus catalyze the reaction. A and B are both false statements, while D is referring to an ordered sequential mechanism, and not necessarily true for all enzyme mechanisms.

Which of the Following Statements Regarding Enzymes Is True