How do misfolded proteins get to the cytoplasm to be destroyed?
A)They diffuse freely through the lipid bilayer.
B)A process called reverse transcription takes proteins back through the translocons they passed through on their way into the ER lumen.
C)They diffuse through gap junctions.
D)An enzyme flips them through the hydrophobic part of the lipid bilayer.
E)Proteins are transported back to the cytosol through the translocon that brought them into the ER lumen or through a separate dislocation channel of uncertain identity.

Question

Quizplus · Accepted Answer

Misfolded proteins are transported back to the cytosol through either the translocon that brought them into the ER lumen or a separate dislocation channel of uncertain identity. This process is known as retrotranslocation or dislocation, and it involves the coordinated action of multiple proteins to escort the misfolded polypeptide chain out of the ER and into the cytosol where it can be degraded by the proteasome. This pathway is important for maintaining ER homeostasis and preventing the accumulation of toxic misfolded proteins in the ER.

How Do Misfolded Proteins Get to the Cytoplasm to Be