On Occasion, Individuals on Antibiotics Such as Minomycin Have an Allergic

On occasion, individuals on antibiotics such as Minomycin have an allergic response to the antibiotic. Symptoms often include an urticarial rash on the skin, and swelling (edema) of the legs and ankles. When this occurs, patients are advised to stop taking the antibiotic, and are treated with corticosteroids. During follow-up visits to their physician, patients are often given a skin test for hypersensitivity to the drug. This skin test involves intradermal injection of a small amount of Minomycin, and 15 minutes later the site of injection is examined for redness and swelling. In cases where this skin test is negative, the patient most likely generated:

A) IgE antibodies to the Minomycin
B) IgG antibodies to the Minomycin
C) CD4 T_H2 cells specific to Minomycin-modified red blood cells
D) CD4 T_H1 cells specific to Minomycin-modified self proteins
E) Activated macrophages that produce IL-1 and TNF- $\alpha$