Hypersensitivity responses to divalent cations such as nickel are relatively common. Individuals sensitized to these metals will develop a skin rash within 15 minutes of putting on a bracelet or ring containing that metal.

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Hypersensitivity responses to divalent cations like nickel are common, but the skin rash or dermatitis usually develops hours to days after exposure, not within 15 minutes.

Hypersensitivity Responses to Divalent Cations Such as Nickel Are Relatively