Diacyl-glycerol (DAG) is one of the two products generated when PLC-$\gamma$ cleaves the membrane phospholipid, PIP₂. This small lipid mediator remains associated with the plasma membrane and functions to inhibit tyrosine phosphatases that remove activating phosphate groups from ZAP-70 and the Tec-family kinase, ITK.

Question

Quizplus · Accepted Answer

Diacyl-glycerol (DAG) is indeed a product generated when phospholipase C (PLC) cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) in the membrane. However, DAG functions primarily as a secondary messenger that activates signaling pathways, such as those involving protein kinase C (PKC), rather than inhibiting tyrosine phosphatases.

Diacyl-Glycerol (DAG) Is One of the Two Products Generated When γ\gammaγ

Diacyl-Glycerol (DAG) Is One of the Two Products Generated When $\gamma$