Human patients with genetic defects that result in a failure to produce the calcium channel protein ORAI1, or the ER calcium sensor protein STIM1, have severe immunodeficiency diseases. An immunosuppressive drug that would most closely mimic these primary immunodeficiencies is:

Question

Quizplus · Accepted Answer

Cyclosporin A is a calcineurin inhibitor that blocks the activation of T cells, leading to reduced immune responses. This mechanism of action is similar to the primary immunodeficiencies caused by the lack of the calcium channel protein ORAI1 and the ER calcium sensor protein STIM1, which also result in impaired T cell activation.

Human Patients with Genetic Defects That Result in a Failure