Scaffold proteins are often phosphorylated at multiple sites, allowing the recruitment of several different signaling proteins. In antigen receptor signaling pathways, this mechanism is used to bring enzymes in close proximity to their substrates. Termination of this signaling mechanism would be most efficiently accomplished by:

Question

Quizplus · Accepted Answer

Dephosphorylation of the scaffold by a phosphatase would remove the multiple phosphorylation sites and prevent the recruitment of signaling proteins, thus terminating the signaling mechanism. Options A, B, and E do not directly address the phosphorylation of the scaffold protein, and option C suggests a passive depletion of the substrate rather than an active regulatory mechanism.

Scaffold Proteins Are Often Phosphorylated at Multiple Sites, Allowing the Recruitment