Question 1

Angiopep-2 targets the ____________.

Accepted Answer

Angiopep-2 targets the low-density lipoprotein receptor-related protein-1 (LRP-1), which is involved in transporting molecules across the blood-brain barrier.

Question 2

COG-133 targets the ___________.

Accepted Answer

COG-133 targets the low-density lipoprotein receptor (LDLR).

Question 3

Conventional liposomes grafted with _____________ are considered to be sterically stable and safe from degradation.

Accepted Answer

Liposomes grafted with a PEG (polyethylene glycol) layer are considered sterically stable because the PEG provides a protective hydrophilic barrier that reduces opsonization and subsequent clearance by the mononuclear phagocyte system, enhancing their stability and circulation time in the bloodstream.

Question 4

___________ consist of one or more concentric spheres of lipid bilayers separated by water or aqueous buffer compartments. Many studies use them as drug carriers in treating diseases of the central nerve system.

Accepted Answer

Liposomes are spherical vesicles with one or more lipid bilayers, used as drug carriers, especially for targeting the central nervous system.

Question 5

____________ are spherical solid particles of a lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants (emulsifiers).

Accepted Answer

Solid Lipid Nanoparticles (SLNs) are spherical solid particles with a lipid core matrix that can solubilize lipophilic molecules, stabilized by surfactants.

Question 6

_____________ is natural polymer and is classified as a linear polysaccharide composed of randomly distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine. It has a positive charge under acidic conditions coming from protonation of its free amino groups.

Accepted Answer

Chitosan is a natural polymer that is a linear polysaccharide composed of randomly distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine. It has a positive charge under acidic conditions due to the protonation of its free amino groups.

Question 7

The mechanism of action of drug delivery by polymeric/lipid carrier systems across the BBB could be attributed to:

Accepted Answer

Polymeric/lipid carrier systems can utilize various mechanisms such as increased retention, surfactant use, tight junction modulation, and endocytosis to enhance drug delivery across the BBB.

Question 8

The novel drug carrier systems for drug targeting to brain have to be:

Accepted Answer

All the listed characteristics are essential for novel drug carrier systems targeting the brain to ensure safety, compatibility with biological systems, effective delivery, and stability within the body.

Question 9

The BBB defense mechanisms in controlling the trafficking of various chemical moieties in and out of the brain,include:

Accepted Answer

The blood-brain barrier (BBB) employs multiple defense mechanisms: tight junctions (A) seal endothelial cells, preventing paracellular transport; lack of fenestrations (B) limits permeability; astrocytic foot processes (C) support the barrier; efflux transport proteins (D) remove unwanted substances; and enzymatic proteins (E) metabolize potentially harmful compounds.

Question 10

The best successful strategy to deliver therapeutic agents to the CNS is:

Accepted Answer

The answer of The best successful strategy to deliver therapeutic...

Question 11

Match the following Term:
___ TEER

Accepted Answer

TEER (Transendothelial Electrical Resistance) is a measure of the integrity and tightness of the barrier formed by endothelial cells, often used to assess the permeability of capillaries.

Question 12

Match the following Term:
___ BBB

Accepted Answer

The term "BBB" stands for the blood-brain barrier, which is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system.

Question 13

Match the following Term:
___ CNS

Accepted Answer

The CNS (Central Nervous System) consists of the brain and spinal cord.

Question 14

Match the following Term:
___ BCSFB

Accepted Answer

The BCSFB (Blood-Cerebrospinal Fluid Barrier) is a highly selective permeability barrier that separates the circulating blood from the cerebrospinal fluid in the central nervous system.

Question 15

Match the following Term:
___ OAT

Accepted Answer

OAT stands for Organic Anion Transporter, which facilitates the transport of organic anions across the blood-brain barrier.

Question 16

Match the following Term:
___ GULT

Accepted Answer

GULT (Glucose Transporter) facilitates the transport of glucose across the blood-brain barrier.

Question 17

What is the BBB and what are its functions?

Accepted Answer

The answer of What is the BBB and what are...

Question 18

What are the BBB defense mechanisms in controlling the trafficking of various chemical moieties in and out of the brain?

Accepted Answer

The answer of What are the BBB defense mechanisms in...

Question 19

What are the physico-chemical properties governing the uptake of CNS drugs into the brain across the BBB?

Accepted Answer

The answer of What are the physico-chemical properties governing the...

Question 20

Why does Benadryl causes drowsiness while Claritin doesn't?

Accepted Answer

The answer of Why does Benadryl causes drowsiness while Claritin...

Quiz 12: Drug Delivery to the CNS: Breaking Down the Barrier

Angiopep-2 targets the ____________.

COG-133 targets the ___________.

Conventional liposomes grafted with _____________ are considered to be sterically stable and safe from degradation.

___________ consist of one or more concentric spheres of lipid bilayers separated by water or aqueous buffer compartments. Many studies use them as drug carriers in treating diseases of the central nerve system.

____________ are spherical solid particles of a lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants (emulsifiers) .

_____________ is natural polymer and is classified as a linear polysaccharide composed of randomly distributed β-(1-4) -linked D-glucosamine and N-acetyl-D-glucosamine. It has a positive charge under acidic conditions coming from protonation of its free amino groups.

The mechanism of action of drug delivery by polymeric/lipid carrier systems across the BBB could be attributed to:

The novel drug carrier systems for drug targeting to brain have to be:

The BBB defense mechanisms in controlling the trafficking of various chemical moieties in and out of the brain,include:

The best successful strategy to deliver therapeutic agents to the CNS is:

Match the following Term: ___ TEER

Match the following Term: ___ BBB

Match the following Term: ___ CNS

Match the following Term: ___ BCSFB

Match the following Term: ___ OAT

Match the following Term: ___ GULT

What is the BBB and what are its functions?

What are the BBB defense mechanisms in controlling the trafficking of various chemical moieties in and out of the brain?

What are the physico-chemical properties governing the uptake of CNS drugs into the brain across the BBB?

Why does Benadryl causes drowsiness while Claritin doesn't?