Lymphocyte activation leads to robust proliferation and effector cell differentiation. The metabolic demands of these processes are met, in part, by up-regulation of glycolytic enzymes and nutrient transporters on the activated cell membrane. A key intermediate in the signaling pathway leading to enhanced glucose metabolism following antigen receptor stimulation is:

Question

Quizplus · Accepted Answer

PIP₃ is a key intermediate in the signaling pathway that enhances glucose metabolism following antigen receptor stimulation, as it is involved in the activation of the Akt pathway, which promotes glucose uptake and glycolysis.

Lymphocyte Activation Leads to Robust Proliferation and Effector Cell Differentiation