The integrin LFA-1 is constitutively expressed on the surface of resting T cells. Yet, integrin-dependent T cell adhesion to antigen-presenting cells increases substantially following TCR stimulation. This increased integrin-dependent adhesion is mediated in part by:

Question

Quizplus · Accepted Answer

T cell activation through TCR stimulation induces LFA-1 conversion from a low to high affinity binding state, allowing for increased binding to its ligands on antigen-presenting cells. There is no evidence that increased synthesis or transport of LFA-1 accounts for the observed increase in adhesion. While LFA-1 phosphorylation and activation of cdc42 and WASp may play a role in integrin-dependent adhesion, they are not the primary mechanisms for the observed increase in adhesion following TCR stimulation.

The Integrin LFA-1 Is Constitutively Expressed on the Surface of Resting