The only mechanism by which CD28 co-stimulation enhances T cell activation is by recruiting and activating PI 3-kinase, leading to Akt activation.

Question

Quizplus · Accepted Answer

While recruitment and activation of PI3-kinase and Akt signaling is an important mechanism by which CD28 co-stimulation enhances T cell activation, it is not the only mechanism. CD28 co-stimulation can also upregulate cytokine production, increase survival and proliferation signals, and enhance metabolic activity of T cells.

The Only Mechanism by Which CD28 Co-Stimulation Enhances T Cell