TCR and CD28 signaling together lead to maximal production of IL-2 by the activated T cell. Experiments investigating the mechanism underlying the CD28 co-stimulation-mediated increase in IL-2 production show that T cells stimulated through the TCR plus CD28 have increased levels of IL-2 mRNA compared to cells stimulated through the TCR alone. One important component contributing to increased IL-2 mRNA levels is:

Question

Quizplus · Accepted Answer

The question specifically mentions increased IL-2 mRNA levels, and mRNA stability after transcription and splicing is the most likely explanation for this increase. Increased protein synthesis (A) and increased glucose metabolism (B) would not directly affect mRNA levels. Enhanced mRNA transport (D) and increased splicing efficiency (E) could both indirectly affect mRNA levels, but the question does not provide any specific information to suggest that these mechanisms are involved. Therefore, C is the best choice.

TCR and CD28 Signaling Together Lead to Maximal Production of IL-2