Humans with defective expression of the integrin LFA-1 have an immunodeficiency disease characterized by the failure of lymphocytes and granulocytes to migrate to tissues at sites of infection or inflammation. A similar immunodeficiency would be expected if individuals had mutations disrupting the gene for:

Question

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Rap1 is involved in the inside-out signaling that activates integrins like LFA-1, so a mutation disrupting Rap1 would impair integrin activation and cell migration, leading to a similar immunodeficiency.

Humans with Defective Expression of the Integrin LFA-1 Have an Immunodeficiency